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Buy Tramadol 100mg online is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatment of moderate to severe pain. It is considered a Step 2 option on the World Health Organization’s pain ladder and has about 1/10th of the potency of morphine.

Tramadol differs from other traditional opioid medications in that it doesn’t just act as a μ-opioid agonist, but also affects mono-amines by modulating the effects of neurotransmitters involved in the modulation of pain such as serotonin and epinephrine which activate descending pain inhibitory pathways.13 Tramadol’s effects on serotonin and nor-epinephrine mimic the effects of other SNRI antidepressants such as fluoxetine and waxiness.

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